Gelatin/hyaluronic acid nanofibrous scaffolds: biomimetics of extracellular matrix

Gelatin/hyaluronic acid nanofibrous scaffolds: biomimetics of extracellular matrix.

In living systems, extracellular matrix (ECM) plays a pivotal role in controlling cell behavior [1]. One of the most significant objectives in tissue engineering is to design and obtain scaffolds with the ability of biomimicking natural ECM in chemical compositions, physical structure, and biological functions [2,3]. Natural ECM is composed of a cross-linked porous network of multifibril collag...

Dynamic culture enhances stem cell infiltration and modulates extracellular matrix production on aligned electrospun nanofibrous scaffolds.

Electrospun nanofibrous scaffolds have become widely investigated for tissue engineering applications, owing to their ability to replicate the scale and organization of many fiber-reinforced soft tissues such as the knee meniscus, the annulus fibrosus of the intervertebral disc, tendon, and cartilage. However, due to their small pore size and dense packing of fibers, cellular ingress into elect...

Nanofibrous scaffolds in biomedical applications

Nanofibrous scaffolds are artificial extracellular matrices which provide natural environment for tissue formation. In comparison to other forms of scaffolds, the nanofibrous scaffolds promote cell adhesion, proliferation and differentiation more efficiently due to having high surface to volume ratio. Although scaffolds for tissue engineering have been fabricated by various techniques but elect...

Comparison of Structural Modification and Argon Plasma Treatment of Poly(lactide-co-glycolic acid) Nanofibrous Scaffolds for Cell Culture

Nanofibrous Scaffolds for Tissue Engineering Applications

The discipline of tissue engineering opens up the ways for repair and regenerate damaged organs and tissues. In the current work biomimetic nanofibrous scaffolds were fabricated by electrospinning. Poly-L-lactic acid (PLLA) was blended with collagen and gelatin to fabricate PLLLA-collagen and PLLA-gelatin fibrous scaffolds respectively. Pure PLLA and gelatin scaffolds served as controls. All th...